Metformin is considered an initial oral pharmacotherapy of choice for treating hyperglycemia in type 2 diabetes mellitus (T2DM). Although safe in the vast majority of the population, rare side effects will come to light as the prevalence of T2DM continues to rise. We present a rare case of metformin-induced hepatotoxicity and possibly the first reported case of dose-dependent metformin-induced hepatotoxicity. This case report aims to make clinicians aware of this infrequent yet significant adverse reaction that can arise with metformin therapy.
Keywords: diabetes; drug-induced liver injury (dili); hepatitis; hepatotoxicity; idiosyncratic liver injury; liver disease; metformin-induced acute hepatitis; metformin-induced hepatotoxicity; metformin-induced lactic acidosis; s: hepatotoxicity.
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