Background: Malignant melanoma in-situ, lentigo maligna (MMIS-LM) can be successfully treated with several different surgical techniques; however, the literature is inconsistent in defining them.
Objective: To comprehensively define and describe the national guideline recommended surgical techniques used to treat MMIS-LM to help clarify and standardize this terminology to ensure compliance with the guidelines.
Methods: A targeted literature review was performed from 1990 to 2022 focusing on articles that discussed the national guideline recommended surgical techniques of wide local excision, Mohs micrographic surgery (MMS), modified Mohs surgery, and staged excision/Slow-Mohs for MMIS-LM, as well as the related methods of tissue processing. National Comprehensive Cancer Network and American Academy of Dermatology guidelines were reviewed to identify how the techniques need to be employed to be compliant with guideline recommendations.
Results: We describe the various surgical and tissue processing techniques and discuss advantages and disadvantages of each.
Limitations: This paper was styled as a narrative review defining and clarifying terminology and technique and does not investigate these topics more broadly.
Conclusion: Understanding the methodology and terminology for these surgical procedures and tissue processing methods is critical so that both general dermatologists and surgeons can employ these techniques effectively for optimal patient care.
Keywords: Mohs micrographic surgery (MMS); Slow-Mohs; en face section; frozen section; horizontal section; lentigo maligna (MMIS-LM); malignant melanoma in situ; modified Mohs; permanent section; staged excision; vertical section; wide local excision.
Published by Elsevier Inc.