Differentiation-Promoting Effects of Okeaniamides A and B from an Okeania sp. Marine Cyanobacterium on Preadipocytes

Kaori Ozaki; Yuka Asato; Noriyuki Natsume; Shunya Tojo; Shimpei Sumimoto; Arihiro Iwasaki; Kiyotake Suenaga; Toshiaki Teruya

doi:10.1021/acs.jnatprod.3c00256

Differentiation-Promoting Effects of Okeaniamides A and B from an Okeania sp. Marine Cyanobacterium on Preadipocytes

J Nat Prod. 2023 Jun 23;86(6):1564-1570. doi: 10.1021/acs.jnatprod.3c00256. Epub 2023 Jun 12.

Authors

Kaori Ozaki¹, Yuka Asato¹, Noriyuki Natsume¹, Shunya Tojo¹, Shimpei Sumimoto², Arihiro Iwasaki³, Kiyotake Suenaga³, Toshiaki Teruya^{1

4}

Affiliations

¹ Graduate School of Engineering and Science, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan.
² Department of Material and Life Chemistry, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama 221-8686, Japan.
³ Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-8522, Japan.
⁴ Faculty of Education, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan.

PMID: 37307100
DOI: 10.1021/acs.jnatprod.3c00256

Abstract

The linear lipopeptides okeaniamide A (1) and okeaniamide B (2) were isolated from an Okeania sp. marine cyanobacterium collected in Okinawa. The structures of these compounds were established by spectroscopic analyses, and the absolute configurations were elucidated based on a combination of chemical degradations, Marfey's analysis, and derivatization reactions. Okeaniamide A (1) and okeaniamide B (2) dose-dependently promoted the differentiation of mouse 3T3-L1 preadipocytes in the presence of insulin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cyanobacteria* / chemistry
Lipopeptides / chemistry
Marine Biology*
Mice
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular

Substances

Lipopeptides