Circ-SHPRH in human cancers: a systematic review and meta-analysis

Hong Xiong; Gaozhen Huang; Yi Zhu; Ruiqi Chen; Ling Zuo; Hongwei Liu

doi:10.3389/fcell.2023.1182900

Circ-SHPRH in human cancers: a systematic review and meta-analysis

Front Cell Dev Biol. 2023 May 25:11:1182900. doi: 10.3389/fcell.2023.1182900. eCollection 2023.

Authors

Hong Xiong¹, Gaozhen Huang¹, Yi Zhu¹, Ruiqi Chen¹, Ling Zuo², Hongwei Liu¹

Affiliations

¹ Laboratory of Urology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
² Department of Traditional Chinese Medicine, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.

Abstract

Circular RNA (circRNA) molecules are noncoding RNAs with ring-like structures formed by covalent bonds and are characterized by no 5'caps or 3'polyadenylated tails. Increasing evidence shows that circRNAs may play an important role in tumorigenesis and cancer metastasis. Circ-SHPRH originates from exons 26-29 of the SHPRH gene, and it is closely associated with human cancers. We searched PubMed, Web of Science, and Embase databases for relevant literatures until 24 December 2022. Eighteen research papers were included in this review, and 11 papers were selected for meta-analysis after screening. Three eligible published studies about circ-SHPRH were enrolled based on their tumor diagnosis aspect, 7 eligible published studies were related to overall survival (OS), and 3 eligible published studies were related to tumor grade. Many studies have shown that circ-SHPRH acts as a miRNA sponge or encodes a protein to regulate downstream genes or signal pathways, and exerts specific biological functions that affect the proliferation, invasion, and apoptosis of cancer cells. Meta-analysis showed that patients with high expression of circ-SHPRH had better OS (HR = 0.53, 95% CI 0.38-0.74, p-value <0.05) and lower TNM stage (HR = 0.33, 95% CI 0.18-0.62, p-value = 0.001). In addition, circ-SHPRH has potential diagnostic value (AUC = 0.8357). This review will help enrich our understanding of the role and mechanism of circ-SHPRH in human cancers. Circ-SHPRH has the potential to be a novel diagnostic and prognostic biomarker for various solid cancers.

Keywords: Circ-SHPRH; biomarker; cancer; circRNA; hsa_circ_0001649.

Publication types

Review

Grants and funding

This study was financially supported by the Guangdong Basic and Applied Basic Research Foundation (2022A1515012195), Medical Scientific Research Foundation of Guangdong Province (B2021127), Zhanjiang Science and Technology Plan Project (2020A01022, 2021A05091, 2022A01017, 2022A01141), and Research Foundation for Advanced Talents of Affiliated Hospital of Guangdong Medical University (20401Z20190003).