Effect of surgical treatment on patients with stage T3 or T4 triple-negative breast cancer: a SEER-based retrospective observational study

Jie Hu; Changling Dai; Yang Zhang; Weijun Chen; Lihua Sun; Xu Zhang; Minjie Duan; Hao Fu; Teng Long; Wei Kang; Chengliang Yin; Xiaozhu Liu; Jie Yu

doi:10.3389/fendo.2023.1184173

Effect of surgical treatment on patients with stage T3 or T4 triple-negative breast cancer: a SEER-based retrospective observational study

Front Endocrinol (Lausanne). 2023 May 26:14:1184173. doi: 10.3389/fendo.2023.1184173. eCollection 2023.

Authors

Jie Hu¹, Changling Dai², Yang Zhang³, Weijun Chen¹, Lihua Sun¹, Xu Zhang⁴, Minjie Duan³, Hao Fu⁵, Teng Long⁶, Wei Kang⁷, Chengliang Yin⁸, Xiaozhu Liu⁹, Jie Yu¹⁰

Affiliations

¹ Department of Tumor Radiotherapy, Taizhou Central Hospital (Affiliated Hospital of Taizhou University), Taizhou, China.
² Department of Hematology, Taizhou Central Hospital (Affiliated Hospital of Taizhou University), Taizhou, China.
³ College of Medical Informatics, Chongqing Medical University, Chongqing, China.
⁴ School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou, China.
⁵ Department of Infectious Disease, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
⁶ Department of Infectious Disease, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
⁷ Department of Mathematics, Physics and Interdisciplinary Studies, Guangzhou Laboratory, Guangzhou, China.
⁸ Faculty of Medicine, Macau University of Science and Technology, Macau, China.
⁹ Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
¹⁰ Department of Medical Imaging, The Affiliated Taian City Central Hospital of Qingdao University, Taian, China.

Abstract

Background: The use of surgery is controversial in patients with stage T3 or T4 triple-negative breast cancer (TNBC). We aimed to explore the effect of surgical treatment on overall survival (OS) of these patients.

Methods: A total of 2,041 patients were selected and divided into the surgical and non-surgical groups based on the Surveillance, Epidemiology, and End Results database from 2010 to 2018. Propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) were applied to balance covariates between different groups. The OS of the two groups were assessed by Kaplan-Meier survival curves and Cox proportional hazards regression models.

Results: A total of 2,041 patients were included in the study. After PSM and IPTW, baseline characteristics of the matched variables were fully balanced. Kaplan-Meier survival curves showed that the median survival time and OS of TNBC patients with stage T3 or T4 in the surgical group were significantly improved compared with those in the non-surgical group. Multivariate Cox proportional hazards regression analysis showed that surgery was a protective factor for prognosis.

Conclusion: Our study found that surgery prolonged the median survival and improved OS compared with the non-surgical group of TNBC patients with stage T3 or T4.

Keywords: median survival; non-surgical group; overall survival; surgical group; triple-negative breast cancer.

Publication types

Observational Study

MeSH terms

Databases, Factual
Humans
Kaplan-Meier Estimate
Multivariate Analysis
Propensity Score
Triple Negative Breast Neoplasms* / surgery