Perivascular adipose tissue in vascular pathologies-a novel therapeutic target for atherosclerotic disease?

Yusuke Adachi; Kazutaka Ueda; Eiki Takimoto

doi:10.3389/fcvm.2023.1151717

Perivascular adipose tissue in vascular pathologies-a novel therapeutic target for atherosclerotic disease?

Front Cardiovasc Med. 2023 May 26:10:1151717. doi: 10.3389/fcvm.2023.1151717. eCollection 2023.

Authors

Yusuke Adachi¹, Kazutaka Ueda¹, Eiki Takimoto¹

Affiliation

¹ Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Abstract

Most blood vessels are surrounded by adipose tissues known as perivascular adipose tissue (PVAT). Emerging experimental data have implicated the potential involvement of PVAT in the pathogenesis of cardiovascular disease: PVAT might be a source of inflammatory mediators under pathological conditions such as metabolic disorders, chronic inflammation, and aging, leading to vascular pathologies, while having vasculo-protective roles in a healthy state. PVAT has been also gaining attention in human disease conditions. Recent integrative omics approaches have greatly enhanced our understanding of the molecular mechanisms underlying the diverse functions of PVAT. This review summarizes recent progress in PVAT research and discusses the potential of PVAT as a target for the treatment of atherosclerosis.

Keywords: atherosclerosis; beiging; brown adipose tissue; inflammation; perivascular adipose tissue; remodeling.

Publication types

Review

Grants and funding

This work was supported by the Japan Society for the Promotion of Science KAKENHI (22K16097), Japan Heart Foundation Research Grant, Japan Foundation for Applied Enzymology, and MSD Life Science Foundation (to Y.A.).