Immune-related adverse events of immune checkpoint inhibitors: a review

Qinan Yin; Liuyun Wu; Lizhu Han; Xingyue Zheng; Rongsheng Tong; Lian Li; Lan Bai; Yuan Bian

doi:10.3389/fimmu.2023.1167975

Immune-related adverse events of immune checkpoint inhibitors: a review

Front Immunol. 2023 May 25:14:1167975. doi: 10.3389/fimmu.2023.1167975. eCollection 2023.

Authors

Qinan Yin^{1

2}, Liuyun Wu^{1

2}, Lizhu Han^{1

2}, Xingyue Zheng^{1

2}, Rongsheng Tong^{1

2}, Lian Li^{1

2}, Lan Bai^{1

2}, Yuan Bian^{1

2}

Affiliations

¹ Department of Pharmacy, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
² Personalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Abstract

Since the first Immune Checkpoint Inhibitor was developed, tumor immunotherapy has entered a new era, and the response rate and survival rate of many cancers have also been improved. Despite the success of immune checkpoint inhibitors, resistance limits the number of patients who can achieve a lasting response, and immune-related adverse events complicate treatment. The mechanism of immune-related adverse events (irAEs) is unclear. We summarize and discuss the mechanisms of action of immune checkpoint inhibitors, the different types of immune-related adverse events and their possible mechanisms, and describe possible strategies and targets for prevention and therapeutic interventions to mitigate them.

Keywords: epidemiology; immune checkpoint inhibitors; immune-related adverse events; management; mechanism.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Immune Checkpoint Inhibitors* / adverse effects
Immunotherapy* / adverse effects

Substances

Immune Checkpoint Inhibitors

Grants and funding

This work has been funded by National Key Research and Development Program of China (2020YFC2005500), the Sichuan Science and Technology Plan Project (2022NSFSC0818, 2023NSFSC0685).