The objective of this study was to evaluate the humoral immune response and the innate response of goats immunized with attenuated vaccine against Corynebacterium pseudotuberculosis prepared from the strain 1002. One hundred goats were divided into 5 groups (n=20 animals/group). Each group was vaccinated as follows: G control: saline solution; G1 - 107 CFU/mL; G2 -107 CFU/mL re-vaccinated within 21 days; G3 - 106 CFU/mL; G4 - 106 CFU/mL revaccinated within 21 days. Blood samples were collected monthly over 12 months and serology was performed through indirect ELISA. In order to verify the innate response through the dosages of acute phase proteins (ceruloplasmin and haptoglobin), samples of five animals from each group were evaluated on days 0, 7, 14, 21, 28 days for the groups G1 and G3, and on days 0, 21, 28, 56 days for the groups G2 and G4. The results showed humoral response activation with the production of immunoglobulins above the cut-off point in all groups. The results showed that strain 1002 vaccine induced the antibody production by the goats' humoral immune system and that the increase in serum concentrations of haptoglobin and ceruloplasmin may be related of the innate immune response.