Protein disulfide isomerases - a way to tackle malaria

Fiona Angrisano; Amelia Ford; Andrew Michael Blagborough; Hayley Elise Bullen

doi:10.1016/j.pt.2023.05.007

Protein disulfide isomerases - a way to tackle malaria

Trends Parasitol. 2023 Aug;39(8):622-625. doi: 10.1016/j.pt.2023.05.007. Epub 2023 Jun 10.

Authors

Fiona Angrisano¹, Amelia Ford², Andrew Michael Blagborough³, Hayley Elise Bullen⁴

Affiliations

¹ Burnet Institute, 85 Commercial Road, Victoria, Australia 3004.
² Division of Microbiology and Parasitology, Department of Pathology, Cambridge University, Tennis Court Road, Cambridge, CB2 1QP, UK.
³ Division of Microbiology and Parasitology, Department of Pathology, Cambridge University, Tennis Court Road, Cambridge, CB2 1QP, UK. Electronic address: amb283@cam.ac.uk.
⁴ Burnet Institute, 85 Commercial Road, Victoria, Australia 3004. Electronic address: hayley.bullen@burnet.edu.au.

PMID: 37302957
DOI: 10.1016/j.pt.2023.05.007

Abstract

Protein disulfide isomerases (PDIs) ensure that specific substrate proteins are correctly folded. PDI activity plays an essential role in malaria transmission. Here we provide an overview of the role of PDIs in malaria-causing Plasmodium parasites and outline why PDI inhibition could be a novel way to treat malaria and prevent transmission.

Keywords: inhibition; malaria; protein disulfide isomerase.

MeSH terms

Humans
Malaria* / drug therapy
Malaria* / prevention & control
Plasmodium* / metabolism
Protein Disulfide-Isomerases / metabolism

Substances

Protein Disulfide-Isomerases

Grants and funding

MR/N00227X/1/MRC_/Medical Research Council/United Kingdom