An international investigation of chlorinated paraffin concentrations and homologue distributions in indoor dust

Thomas J McGrath; Giulia Poma; Sébastien Hutinet; Yukiko Fujii; Robin E Dodson; Boris Johnson-Restrepo; Dudsadee Muenhor; Gaud Dervilly; Ronan Cariou; Adrian Covaci

doi:10.1016/j.envpol.2023.121994

An international investigation of chlorinated paraffin concentrations and homologue distributions in indoor dust

Environ Pollut. 2023 Sep 15:333:121994. doi: 10.1016/j.envpol.2023.121994. Epub 2023 Jun 9.

Authors

Affiliations

¹ Toxicological Centre, University of Antwerp, 2610, Wilrijk, Belgium; Oniris, INRAE, LABERCA, 44300, Nantes, France. Electronic address: thomas.mcgrath@uantwerpen.be.
² Toxicological Centre, University of Antwerp, 2610, Wilrijk, Belgium.
³ Oniris, INRAE, LABERCA, 44300, Nantes, France.
⁴ Toxicological Centre, University of Antwerp, 2610, Wilrijk, Belgium; Daiichi University of Pharmacy, Fukuoka, 815-8511, Japan.
⁵ Silent Spring Institute, Newton, MA, USA, 02460.
⁶ Environmental Chemistry Research Group, University of Cartagena, Cartagena, 130015, Colombia.
⁷ Faculty of Environmental Management, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand; Health Impact Assessment Research Center, Prince of Songkla University, Hat Yai, Songkhla, 90110, Thailand; Center of Excellence on Hazardous Substance Management (HSM), Bangkok, 10330, Thailand.

PMID: 37302785
DOI: 10.1016/j.envpol.2023.121994

Abstract

In this study, very short-, short-, medium-, and long-chain chlorinated paraffins (vSCCPs, SCCPs, MCCPs and LCCPs, respectively) were measured in 40 indoor dust samples from four countries including Japan (n = 10), Australia (n = 10), Colombia (n = 10) and Thailand (n = 10). Homologues of the chemical formula C_xH_(2x+2-y)Cl_y ranging C_6-36 and Cl_3-30 were analysed using liquid chromatography coupled to Orbitrap high resolution mass spectrometry (LC-Orbitrap-HRMS) and integrated using novel custom-built CP-Seeker software. CPs were detected in all dust samples with MCCPs the dominant homologue group in all countries. Overall median ∑SCCP, ∑MCCP and ∑LCCP (C_18-20) concentrations determined in dust samples were 30 μg/g (range; 4.0-290 μg/g), 65 μg/g (range; 6.9-540 μg/g) and 8.6 μg/g (range; <1.0-230 μg/g), respectively. Of the quantified CP classes, overall concentrations were generally highest in the samples from Thailand and Colombia, followed by Australia and Japan. vSCCPs with C_≤₉ were detected in dust from each country with an overall frequency of 48%, while LCCPs (C_21-36) were present in 100% of samples. Estimated daily intakes (EDIs) calculated for SCCPs and MCCPs relating to ingestion of contaminated indoor dust were considered not to represent health risks based on currently available toxicological data using the margin of exposure (MOE) approach. To the authors' knowledge, this study provides the first data on CPs in indoor dust from Japan, Colombia and Thailand, and is among the first reports of vSCCPs in indoor dust, globally. These findings indicate that further toxicological data and the availability of appropriate analytical standards are needed to evaluate the potential for negative health outcomes deriving from exposure to vSCCPs and LCCPs.

Keywords: Chlorinated paraffins (CPs); Human exposure; Indoor dust; Liquid chromatography-high resolution mass spectrometry (LC-HRMS).

MeSH terms

China
Dust / analysis
Environmental Monitoring* / methods
Hydrocarbons, Chlorinated* / analysis
Mass Spectrometry
Paraffin / analysis

Substances

Hydrocarbons, Chlorinated
Paraffin
Dust