Synthesis and biological evaluation of biotinylated ZJ-101

Shan Qian; Sarah A Head; Phillip R Sanchez; Jun O Liu; Zhendong Jin

doi:10.1016/j.bmcl.2023.129372

Synthesis and biological evaluation of biotinylated ZJ-101

Bioorg Med Chem Lett. 2023 Jul 15:91:129372. doi: 10.1016/j.bmcl.2023.129372. Epub 2023 Jun 8.

Authors

Shan Qian¹, Sarah A Head², Phillip R Sanchez², Jun O Liu³, Zhendong Jin⁴

Affiliations

¹ Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA.
² Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe St., Baltimore, MD 21205, USA.
³ Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, 725 North Wolfe St., Baltimore, MD 21205, USA; Department of Oncology, Johns Hopkins University School of Medicine, 725 North Wolfe St., Baltimore, MD 21205, USA.
⁴ Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, The University of Iowa, Iowa City, IA 52242, USA. Electronic address: zhendong-jin@uiowa.edu.

PMID: 37301523
PMCID: PMC10330923 (available on 2024-07-15)
DOI: 10.1016/j.bmcl.2023.129372

Abstract

ZJ-101 is a structurally simplified analog of marine natural product superstolide A that was previously designed and synthesized in our laboratory. Biological investigation shows that ZJ-101 maintains the potent anticancer activity of the original natural product with an undefined mechanism of action. To facilitate chemical biology study, a biotinylated ZJ-101 was synthesized and biologically evaluated.

Keywords: Anticancer agent; Biotinylated probe; Superstolide A; ZJ-101.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Biological Products* / pharmacology
Drug Screening Assays, Antitumor
Macrolides* / pharmacology
Tetrahydronaphthalenes / pharmacology

Substances

ZJ-101
Macrolides
Tetrahydronaphthalenes
Biological Products

Abstract

Publication types

MeSH terms

Substances

Grants and funding