Noncoding RNA circuitry in melanoma onset, plasticity, and therapeutic response

Katerina Grafanaki; Ioannis Grammatikakis; Arin Ghosh; Vishaka Gopalan; Gulden Olgun; Huaitian Liu; George C Kyriakopoulos; Ilias Skeparnias; Sophia Georgiou; Constantinos Stathopoulos; Sridhar Hannenhalli; Glenn Merlino; Kerrie L Marie; Chi-Ping Day

doi:10.1016/j.pharmthera.2023.108466

Noncoding RNA circuitry in melanoma onset, plasticity, and therapeutic response

Pharmacol Ther. 2023 Aug:248:108466. doi: 10.1016/j.pharmthera.2023.108466. Epub 2023 Jun 8.

Authors

Affiliations

¹ Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA; Department of Dermatology, School of Medicine, University of Patras, 26504 Patras, Greece.
² Cancer Genetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
³ Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
⁴ Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
⁵ Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
⁶ Department of Biochemistry, School of Medicine, University of Patras, 26504 Patras, Greece.
⁷ Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
⁸ Department of Dermatology, School of Medicine, University of Patras, 26504 Patras, Greece.
⁹ Division of Molecular and Cellular Function, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. Electronic address: kerrie.marie@manchester.ac.uk.
¹⁰ Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. Electronic address: chi-ping.day@nih.gov.

Abstract

Melanoma, the cancer of the melanocyte, is the deadliest form of skin cancer with an aggressive nature, propensity to metastasize and tendency to resist therapeutic intervention. Studies have identified that the re-emergence of developmental pathways in melanoma contributes to melanoma onset, plasticity, and therapeutic response. Notably, it is well known that noncoding RNAs play a critical role in the development and stress response of tissues. In this review, we focus on the noncoding RNAs, including microRNAs, long non-coding RNAs, circular RNAs, and other small RNAs, for their functions in developmental mechanisms and plasticity, which drive onset, progression, therapeutic response and resistance in melanoma. Going forward, elucidation of noncoding RNA-mediated mechanisms may provide insights that accelerate development of novel melanoma therapies.

Keywords: Circular RNAs (circRNAs); Developmental state; Lineage; Long non-coding RNAs (lncRNAs); Melanoma; Non-coding RNAs (ncRNAs); Plasticity; Translational plasticity; microRNAs (miRNAs).

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Intramural

MeSH terms

Humans
Melanoma* / drug therapy
Melanoma* / genetics
MicroRNAs* / genetics
MicroRNAs* / metabolism
RNA, Circular
RNA, Long Noncoding* / genetics
RNA, Untranslated / genetics

Substances

RNA, Untranslated
MicroRNAs
RNA, Long Noncoding
RNA, Circular

Abstract

Publication types

MeSH terms

Substances

Grants and funding