Hedgehog signalling in allograft vasculopathy: a new therapeutic target?

Jasmine Rowell; Ching-In Lau; Diana C Yánez; Eden Zhang; Tessa Crompton

doi:10.1016/j.tips.2023.05.005

Hedgehog signalling in allograft vasculopathy: a new therapeutic target?

Trends Pharmacol Sci. 2023 Sep;44(9):558-560. doi: 10.1016/j.tips.2023.05.005. Epub 2023 Jun 7.

Authors

Jasmine Rowell¹, Ching-In Lau¹, Diana C Yánez¹, Eden Zhang¹, Tessa Crompton²

Affiliations

¹ UCL Great Ormond Street Institute of Child Health, London, UK.
² UCL Great Ormond Street Institute of Child Health, London, UK. Electronic address: t.crompton@ucl.ac.uk.

PMID: 37296035
DOI: 10.1016/j.tips.2023.05.005

Abstract

Allograft vasculopathy (AV) leads to chronic rejection of organ transplants, but its causes are obscure. New research from the Jane-Wit laboratory showed that Sonic Hedgehog (SHH) signalling from damaged graft endothelium drives vasculopathy by promoting proinflammatory cytokine production and NLRP3-inflammasome activation in alloreactive CD4⁺PTCH1^hiPD-1^hiT memory cells, offering new diagnostic and therapeutic strategies.

Keywords: CD4 T cell; NLRP3; SMO; Sonic Hedgehog (SHH); ZFYVE21; inflammasome.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Allografts
Hedgehog Proteins* / physiology
Humans
Signal Transduction* / physiology

Substances

Hedgehog Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding