Effect of 20 μm thin ceramic coatings of hydroxyapatite, bioglass, GB14 and Beta-Tricalciumphosphate with copper on the biomechanical stability of femoral implants

Philip Przybilla; Eugen Subkov; Sergio H Latorre; Sergej Zankovic; Hermann O Mayr; Andreas Killinger; Hagen Schmal; Michael Seidenstuecker

doi:10.1016/j.jmbbm.2023.105951

Effect of 20 μm thin ceramic coatings of hydroxyapatite, bioglass, GB14 and Beta-Tricalciumphosphate with copper on the biomechanical stability of femoral implants

J Mech Behav Biomed Mater. 2023 Aug:144:105951. doi: 10.1016/j.jmbbm.2023.105951. Epub 2023 Jun 2.

Authors

Philip Przybilla¹, Eugen Subkov², Sergio H Latorre², Sergej Zankovic², Hermann O Mayr², Andreas Killinger³, Hagen Schmal², Michael Seidenstuecker⁴

Affiliations

¹ G.E.R.N. Center of Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Medical Center-Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106, Freiburg, Germany; Department of Orthopaedics and Traumatology, University Hospital of Basel, Spitalstrasse 21, 4031, Basel, Switzerland.
² G.E.R.N. Center of Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Medical Center-Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106, Freiburg, Germany.
³ Institute for Manufacturing Technologies of Ceramic Components and Composites (IMTCCC), Faculty 07, University of Stuttgart, Allmandring 7b, 70569, Stuttgart, Germany.
⁴ G.E.R.N. Center of Tissue Replacement, Regeneration & Neogenesis, Department of Orthopedics and Trauma Surgery, Medical Center-Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106, Freiburg, Germany. Electronic address: michael.seidenstuecker@uniklinik-freiburg.de.

PMID: 37295386
DOI: 10.1016/j.jmbbm.2023.105951

Abstract

In the present work, we test four thin coatings for titanium implants, namely, bioglass, GB14, Beta-Tricalciumphosphate (β-TCP) and hydroxyapatite (HA) with and without incorporated copper ions for their osteointegrative capacity. A rabbit drill hole model for time intervals up to 24 weeks was used in this study. Implant fixation was evaluated by measuring shear strength of the implant/bone interface. Quantitative histological analysis was performed for the measurements of bone contact area. Implants with and without copper ions were compared after 24 weeks. Thin coatings of GB14, HA or TCP on titanium implants demonstrated high shear strength during the entire test period of up to 24 weeks. Results confirmed osteointegrative properties of the coatings and did not reveal any negative effect of copper ions on osteointegration. The integration of copper in degradable osteoconductive coatings with a thickness of approx. 20 μm represents a promising method of achieving antibacterial shielding during the entire period of bone healing while at the same time improving osteointegration of the implants.

Keywords: Copper; Hydroxyapatite; Implant; Rabbit; Shear strength; Tricalciumphosphate.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Ceramics
Coated Materials, Biocompatible / pharmacology
Copper*
Durapatite*
Osseointegration
Rabbits
Surface Properties
Titanium

Substances

Durapatite
Bioglass
Copper
Titanium
tricalcium phosphate
Coated Materials, Biocompatible