The effects and underlying mechanism of extracorporeal shockwave therapy on fracture healing

Fuxian Lv; Zhenlan Li; Yuling Jing; Liyuan Sun; Zhiwei Li; Haoyang Duan

doi:10.3389/fendo.2023.1188297

The effects and underlying mechanism of extracorporeal shockwave therapy on fracture healing

Front Endocrinol (Lausanne). 2023 May 24:14:1188297. doi: 10.3389/fendo.2023.1188297. eCollection 2023.

Authors

Fuxian Lv¹, Zhenlan Li¹, Yuling Jing¹, Liyuan Sun¹, Zhiwei Li¹, Haoyang Duan¹

Affiliation

¹ Department of Rehabilitation Medicine, First Hospital of Jilin University, Chang chun, China.

Abstract

The clinical efficacy of ESWT in treating bone non union has been widely recognized, but the biological mechanism of ESWT promoting bone non union healing is still unclear. ESWT can make old callus micro fracture through mechanical conduction, form subperiosteal hematoma, promote the release of bioactive factors, reactivate the fracture healing mechanism, rebalance the activities of osteoblasts and osteoclast, promote the angiogenesis of fracture site, and accelerate the healing of bone nonunion.Over recent years, great efforts have been made by both scientists and clinicians to explore the underlying mechanism behind the healing effect of ESWT on bone fractures. In this review, we introduced the growth factors during osteogenesis induced by ESWT hoping to provide new insights in the clinical use of ESWT.

Keywords: extracorporeal shockwave therapy; fracture; growth factor; osteogenesis; review.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Bone Diseases*
Extracorporeal Shockwave Therapy*
Fracture Healing
Fractures, Bone* / therapy
Humans
Treatment Outcome

Grants and funding

This work was supported by grants from Science and technology achievements transformation fund of the First Hospital of Jilin University (No. JDYYZH-2022012).