Iridoids and active ones in patrinia: A review

Li Wang; Xinjing Meng; Huihui Zhou; Yuhang Liu; Yadan Zhang; Haiyang Liang; Gaixia Hou; Wenyi Kang; Zhenhua Liu

doi:10.1016/j.heliyon.2023.e16518

Iridoids and active ones in patrinia: A review

Heliyon. 2023 May 26;9(6):e16518. doi: 10.1016/j.heliyon.2023.e16518. eCollection 2023 Jun.

Authors

Li Wang^{1

2}, Xinjing Meng^{1

2}, Huihui Zhou^{1

3}, Yuhang Liu^{1

3}, Yadan Zhang^{1

3}, Haiyang Liang^{1

3}, Gaixia Hou^{4

1}, Wenyi Kang^{1

3

5}, Zhenhua Liu^{1

3

5}

Affiliations

¹ National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, China.
² Functional Food Engineering Technology Research Center, Henan, Kaifeng, 475004, China.
³ Joint International Research Laboratory of Food & Medicine Resource Function, Henan Province, Kaifeng 475004, China.
⁴ College of Physical Education, Henan University, Henan, Kaifeng, 475004, China.
⁵ Shenzhen Research Institute of Henan University, Shenzhen, 518000, China.

Abstract

Iridoid is a special class of monoterpenoids, whose basic skeleton is the acetal derivative of antinodilaldehyde with a bicyclic H-5/H-9β, β-cisfused cyclopentan pyran ring. They were often existed in Valerianaceae, Rubiaceae, Scrophulariaceae and Labiaceae family, and has various biological activities, such as anti-inflammatory, hypoglycemic, neuroprotection, and soon. In this review, iridoids from Patrinia (Valerianaceae family), and the active ones as well as their mechanisms in recent 20 years were summarized. Up to now, a total of 115 iridoids had been identified in Patrinia, among which 48 had extensive biological activities mainly presented in anti-inflammatory, anti-tumor and neuroprotective. And the mechanisms involved in MAPK, NF-κB and JNK signal pathways. The summary for iridoids and their activities will provide the evidence to exploit the iridoids in Patrinia.

Keywords: Biological activity; Iridoid; Patrinia; Structure classification.