MICU1 deficiency alters mitochondrial morphology and cytochrome C release

Cell Calcium. 2023 Jul:113:102765. doi: 10.1016/j.ceca.2023.102765. Epub 2023 Jun 2.

Abstract

The mitochondrial inner boundary membrane harbors a protein called MICU1, which is sensitive to Ca2+ and binds to the MICOS components Mic60 and CHCHD2. Changes in the mitochondrial cristae junction structure and organization in MICU1-/- cells lead to increased cytochrome c release, membrane potential rearrangement, and changes in mitochondrial Ca2+ uptake dynamics. These findings shed new light on the multifaceted role of MICU1, highlighting its involvement not only as an interaction partner and regulator of the MCU complex but also as a crucial determinant of mitochondrial ultrastructure and, thus, an essential player in processes initiating apoptosis.

Keywords: Apoptosis; Ca(2+) signaling; Cristae junction; MICOS-complex; MICU1; Mitochondria.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Calcium-Binding Proteins / metabolism
  • Cytochromes c* / metabolism
  • Mitochondria / metabolism
  • Mitochondrial Membrane Transport Proteins* / metabolism
  • Mitochondrial Membranes / metabolism

Substances

  • Cytochromes c
  • Mitochondrial Membrane Transport Proteins
  • Calcium-Binding Proteins