Functional role of circRNAs in osteogenesis: A review

Ahmed Hjazi; Bayu Indra Sukmana; Sally Saad Ali; Hashem O Alsaab; Jitendra Gupta; Muhammad Ikram Ullah; Rosario Mireya Romero-Parra; Ahmed H R Alawadi; Adeeb Abdulally Abdulhussien Alazbjee; Yasser Fakri Mustafa

doi:10.1016/j.intimp.2023.110455

Functional role of circRNAs in osteogenesis: A review

Int Immunopharmacol. 2023 Aug:121:110455. doi: 10.1016/j.intimp.2023.110455. Epub 2023 Jun 6.

Affiliations

¹ Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia.
² Department of Oral Biology, Faculty of Dentistry, Lambung Mangkurat University, Banjarmasin, Indonesia.
³ College of Dentistry, Al-Bayan University, Baghdad, Iraq.
⁴ Pharmaceutics and Pharmaceutical Technology, Taif University, Taif, Saudi Arabia.
⁵ Institute of Pharmaceutical Research, GLA University, Mathura, Pin Code 281406 U.P., India.
⁶ Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka 75471, Aljouf, Saudi Arabia.
⁷ Department of General Studies, Universidad Continental, Lima, Peru. Electronic address: rosarioromeroparra@gmail.com.
⁸ Medical Analysis Department, College of Medical Technology, The Islamic University, Najaf, Iraq.
⁹ Collage of Medicin, Al-Ayen University, Thi-Qar, Iraq.
¹⁰ Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul-41001, Iraq.

PMID: 37290324
DOI: 10.1016/j.intimp.2023.110455

Abstract

The extracellular matrixes (ECM), as well as the microenvironmental signals, play an essential role in osteogenesis by regulating intercellular pathways. Recently, it has been demonstrated that a newly identified RNA, circular RNA, contributes to the osteogenesis process. Circular RNA (circRNA), the most recently identified RNA, is involved in the regulation of gene expression at transcription to translation levels. The dysregulation of circRNAs has been observed in several tumors and diseases. Also, various studies have shown that circRNAs expression is changed during osteogenic differentiation of progenitor cells. Therefore, understanding the role of circRNAs in osteogenesis might help the diagnosis as well as treatment of bone diseases such as bone defects and osteoporosis. In this review, circRNA functions and the related pathways in osteogenesis have been discussed.

Keywords: Bone fracture; Circular RNAs; Differentiation; Stem cells; miRNA sponges.

Publication types

Review

MeSH terms

Animals
Bone Diseases / therapy
Cell Differentiation
Gene Expression
Humans
Osteogenesis*
RNA, Circular* / genetics
RNA, Circular* / metabolism
Signal Transduction
Tissue Engineering

Substances

RNA, Circular