Curcumin in exfoliated layered double hydroxide nanoparticles: Pre-clinical evaluation as lung cancer nanomedicine

Sanoj Rejinold N; Huiyan Piao; Goeun Choi; Jin-Ho Choy

doi:10.1016/j.colsurfb.2023.113386

Curcumin in exfoliated layered double hydroxide nanoparticles: Pre-clinical evaluation as lung cancer nanomedicine

Colloids Surf B Biointerfaces. 2023 Aug:228:113386. doi: 10.1016/j.colsurfb.2023.113386. Epub 2023 May 30.

Authors

Sanoj Rejinold N¹, Huiyan Piao¹, Goeun Choi², Jin-Ho Choy³

Affiliations

¹ Intelligent Nanohybrid Materials Laboratory (INML), Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, the Republic of Korea.
² Intelligent Nanohybrid Materials Laboratory (INML), Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, the Republic of Korea; College of Science and Technology, Dankook University, Cheonan 31116, the Republic of Korea; Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, the Republic of Korea.
³ Intelligent Nanohybrid Materials Laboratory (INML), Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, the Republic of Korea; Department of Pre-medical Course, College of Medicine, Dankook University, Cheonan 31116, the Republic of Korea; Division of Natural Sciences, The National Academy of Sciences, Seoul 06579, the Republic of Korea; International Research Frontier Initiative (IRFI), Institute of Innovative Research, Tokyo Institute of Technology, Yokohama 226-8503, Japan. Electronic address: jhchoy@dankook.ac.kr.

PMID: 37290202
DOI: 10.1016/j.colsurfb.2023.113386

Abstract

Rationally designed ∼ 100 nm sized curcumin (CRC) loaded exfoliated layered double hydroxide nanoparticles (X-LDH/CRC-NPs) have been tested for its suitability as nanomedicine in non-small cell lung cancer (NSCLC) cell lines (A549 and NCI-H460) resulting enhanced apoptosis. Preclinical evaluation on A549 tumor bearing nude mouse model confirmed that such a well-designed X-LDH/CRC NPs would be highly advantageous for treating lung cancers.

Keywords: Curcumin; Exfoliated LDH (Layered double hydroxide); In vivo efficacy; Lung cancer therapy.

MeSH terms

Animals
Carcinoma, Non-Small-Cell Lung* / drug therapy
Cell Line, Tumor
Curcumin* / pharmacology
Curcumin* / therapeutic use
Hydroxides
Lung Neoplasms* / pathology
Mice
Nanomedicine / methods
Nanoparticles*

Substances

Curcumin
Hydroxides