Association of 25(OH)-Vitamin D and metabolic factors with colorectal polyps

Chih-Hsiang Chiang; Yu-Jun Chang; Sin-Ru He; Jih-Ning Chao; Chih-Huai Yang; Yen-Tze Liu

doi:10.1371/journal.pone.0286654

Association of 25(OH)-Vitamin D and metabolic factors with colorectal polyps

PLoS One. 2023 Jun 8;18(6):e0286654. doi: 10.1371/journal.pone.0286654. eCollection 2023.

Authors

Chih-Hsiang Chiang¹, Yu-Jun Chang², Sin-Ru He¹, Jih-Ning Chao³, Chih-Huai Yang¹, Yen-Tze Liu^{1

2

4}

Affiliations

¹ Department of Family Medicine, Changhua Christian Hospital, Changhua, Taiwan.
² Big Data Center, Changhua Christian Hospital, Changhua, Taiwan.
³ Institute of Statistics, National Chung Hsing University, Taichung City, Taiwan.
⁴ Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan.

Abstract

Background: Studies have revealed the association of vitamin D with specific types of cancer development, however, its correlation with colorectal polyps (CRPs) remains unverified. Our study aimed to investigate the relationship between vitamin D levels, metabolic factors, and CRPs.

Methods: A cross-sectional study from 2017 to 2019 involving 1306 participants was conducted to investigate the association among vitamin D levels, metabolic factors, uric acid and CRPs in Taiwan. CRPs diagnoses were determined via colonoscopies conducted by experienced gastrointestinal physicians, and biopsied polyps were inspected under a microscope by experienced pathologists. We employed both simple and multiple logistic regression analyses to identify significant factors associated with CRPs and adenomatous polyps, respectively.

Results: Our result showed that the prevalence of 25(OH)-vitamin D deficiency (≦ 20 ng/mL) and CRPs was 21.21% and 40.89%, respectively. Multiple logistic regression revealed that the risk of CRPs increased with old age, male sex, hyperglycemia, high triglyceride levels, and low 25(OH)D levels after adjustment for other factors. Besides, low 25(OH)D levels were significantly associated with CRPs risk in women, whereas elevated blood pressure was associated with CRPs risk in men. 25(OH)D Deficiency was revealed to be significantly associated with risk of CRPs in adults over 50 years old. Compared to nonadenomatous polyps, older age, higher 25(OH) vitamin D and higher uric acid levels were at increased risk for adenomatous polyps.

Conclusions: Our study revealed that vitamin D deficiency was significantly associated with the risk of CRPs, especially in adults over 50 years old and women. We should therefore be concerned about the CRP risk of vitamin D deficiency and metabolic syndrome (especially hyperglycemia, elevated blood pressure in men, and high triglyceride levels) in this population.

Copyright: © 2023 Chiang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenomatous Polyps*
Adult
Colonic Polyps* / epidemiology
Cross-Sectional Studies
Female
Humans
Hyperglycemia* / complications
Male
Metabolic Syndrome* / complications
Metabolic Syndrome* / epidemiology
Middle Aged
Prevalence
Risk Factors
Triglycerides
Uric Acid
Vitamin D
Vitamin D Deficiency* / complications
Vitamin D Deficiency* / epidemiology
Vitamins

Substances

Vitamin D
Uric Acid
Vitamins
Triglycerides

Grants and funding

This study was funded by the Changhua Christian Hospital (109-CCH-IRP-031). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. All authors have no financial relationships with any organizations that might have an interest in the submitted work; no other relationships or activities that could appear to have influenced the submitted work.