Magnetic Bead Manipulation in Microfluidic Chips for Biological Application

Gaozhe Cai; Zixin Yang; Yu-Cheng Chen; Yaru Huang; Lijuan Liang; Shilun Feng; Jianlong Zhao

doi:10.34133/cbsystems.0023

Magnetic Bead Manipulation in Microfluidic Chips for Biological Application

Cyborg Bionic Syst. 2023 Apr 14:4:0023. doi: 10.34133/cbsystems.0023. eCollection 2023.

Authors

Gaozhe Cai¹, Zixin Yang², Yu-Cheng Chen³, Yaru Huang^{1

4}, Lijuan Liang¹, Shilun Feng^{1

5}, Jianlong Zhao^{1

5

6}

Affiliations

¹ State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
² School of Communication and Information Engineering, Shanghai University, Shanghai 200444, China.
³ School of Electrical and Electronics Engineering, Nanyang Technological University, 50 Nanyang Ave., Singapore 639798, Singapore.
⁴ School of Life Sciences, Shanghai Normal University, Shanghai, 200235, China.
⁵ Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China.
⁶ Xiangfu Laboratory, Jiaxing, Zhejiang 314102, China.

Abstract

Magnetic beads manipulation in microfluidic chips is a promising research field for biological application, especially in the detection of biological targets. In this review, we intend to present a thorough and in-depth overview of recent magnetic beads manipulation in microfluidic chips and its biological application. First, we introduce the mechanism of magnetic manipulation in microfluidic chip, including force analysis, particle properties, and surface modification. Then, we compare some existing methods of magnetic manipulation in microfluidic chip and list their biological application. Besides, the suggestions and outlook for future developments in the magnetic manipulation system are also discussed and summarized.