Long-term variations and influential factors of the treatment zone of wearing orthokeratology lenses

Jingxin Li; Jie Hu; Xuewei Li; Jiyang Tang; Yan Li; Kai Wang; Mingwei Zhao

doi:10.1016/j.clae.2023.101867

Long-term variations and influential factors of the treatment zone of wearing orthokeratology lenses

Cont Lens Anterior Eye. 2023 Aug;46(4):101867. doi: 10.1016/j.clae.2023.101867. Epub 2023 Jun 5.

Authors

Jingxin Li¹, Jie Hu¹, Xuewei Li², Jiyang Tang¹, Yan Li², Kai Wang³, Mingwei Zhao²

Affiliations

¹ Department of Ophthalmology & Clinical Center of Optometry, Peking University People's Hospital, Beijing 100044, China; College of Optometry, Peking University Health Science Center, Beijing, China; Department of Ophthalmology, Eye Disease and Optometry Institute, Peking University People's Hospital, China; Department of Ophthalmology, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, China.
² Department of Ophthalmology & Clinical Center of Optometry, Peking University People's Hospital, Beijing 100044, China; College of Optometry, Peking University Health Science Center, Beijing, China; Department of Ophthalmology, Eye Disease and Optometry Institute, Peking University People's Hospital, China; Department of Ophthalmology, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, China; Department of Optometry, Institute of Medical Technology, Peking University Health Science Center, Beijing 100044, China.
³ Department of Ophthalmology & Clinical Center of Optometry, Peking University People's Hospital, Beijing 100044, China; College of Optometry, Peking University Health Science Center, Beijing, China; Department of Ophthalmology, Eye Disease and Optometry Institute, Peking University People's Hospital, China; Department of Ophthalmology, Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, China; Department of Optometry, Institute of Medical Technology, Peking University Health Science Center, Beijing 100044, China. Electronic address: wang_kai@bjmu.edu.cn.

PMID: 37286433
DOI: 10.1016/j.clae.2023.101867

Abstract

Purpose: To investigate the variation trend of the treatment zone (TZ) during 12 months of Orthokeratology (Ortho-K) from the perspective of the treatment zone size (TZS), decentration (TZD) and the weighted Zernike defocus coefficient of the treatment zone (C_{weighteddefocus}).

Methods: 94 patients were included in this retrospective study, who were fitted with a 5-curve vision shaping treatment (VST) lens (n = 44) or a 3-zone corneal refractive therapy (CRT) lens (n = 50). The TZS, TZD and C_{weighteddefocus} up to 12 months were analyzed.

Results: TZS (F(4,372) = 10.167, P＜0.001), TZD (F(4,372) = 8.083, P＜0.001) and C_{weighteddefocus} (F(4,372) = 7.100, P＜0.001) were significantly increased with time during overnight Ortho-K treatment. The TZS increased sharply from 1 week to 1 month of overnight Ortho-K (F = 25.479, P <.001) and stayed smooth then. It showed growing tendency from 6 to 12 months (F = 8.407, P =.005). The TZD (F = 16.637, P <.001) and C_{weighteddefocus} (F = 13.401, P <.001) increased significantly until 1 month and kept stable until 12 months (all P＞0.05). The univariant linear regression analysis showed that TZS of the last visit was correlated with baseline myopia (β = 0.219, P =.034). Also, the greater final C_{weighteddefocus} was correlated with higher baseline myopia (β = -0.589, P＜0.001) and higher corneal astigmatism (β = -0.228, P =.007) at the onset of lens wear with the multiple linear regression.

Conclusion: The TZS, TZD and C_{weighteddefocus} kept stable after 1 month of Ortho-K while the TZS had an increasing trend after 6 months. Children with higher myopic eyes or higher corneal astigmatism at baseline tended to have smaller TZS and greater C_{weighteddefocus} at 12 months.

Keywords: Long-term; Orthokeratology; Treatment zone; Zernike.

MeSH terms

Astigmatism* / therapy
Child
Contact Lenses*
Cornea
Corneal Diseases*
Corneal Topography
Humans
Myopia* / therapy
Orthokeratologic Procedures*
Refraction, Ocular
Retrospective Studies