Targeting the dynamics of cancer metabolism in the era of precision oncology

Peijie Zheng; Zihao Lin; Yuemin Ding; Shiwei Duan

doi:10.1016/j.metabol.2023.155615

Targeting the dynamics of cancer metabolism in the era of precision oncology

Metabolism. 2023 Aug:145:155615. doi: 10.1016/j.metabol.2023.155615. Epub 2023 Jun 5.

Authors

Peijie Zheng¹, Zihao Lin², Yuemin Ding³, Shiwei Duan⁴

Affiliations

¹ Department of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou 310015, China. Electronic address: peijiezheng@stu.zucc.edu.cn.
² Department of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou 310015, China. Electronic address: zihaolin@stu.zucc.edu.cn.
³ Department of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou 310015, China; Institute of Translational Medicine, Hangzhou City University, Hangzhou 310015, China; Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, Hangzhou City University, Hangzhou 310015, China. Electronic address: dingyuemin@zucc.edu.cn.
⁴ Department of Clinical Medicine, School of Medicine, Hangzhou City University, Hangzhou 310015, China; Institute of Translational Medicine, Hangzhou City University, Hangzhou 310015, China; Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province, Hangzhou City University, Hangzhou 310015, China. Electronic address: duansw@zucc.edu.cn.

PMID: 37286129
DOI: 10.1016/j.metabol.2023.155615

Abstract

Cancer metabolic reprogramming is a promising target for cancer therapy. The progression of tumors, including their growth, development, metastasis, and spread, is a dynamic process that varies over time and location. This means that the metabolic state of tumors also fluctuates. A recent study found that energy production efficiency is lower in solid tumors but increases significantly in tumor metastasis. Despite its importance for targeted tumor metabolism therapy, few studies have described the dynamic metabolic changes of tumors. In this commentary, we discuss the limitations of past targeted tumor metabolism therapy and the key findings of this study. We also summarize its immediate clinical implications for dietary intervention and explore future research directions for understanding the dynamic changes in tumor metabolic reprogramming.

Keywords: ATP; Biological rhythms; Cancer; Dietary therapy; Metabolic reprogramming; Tumor.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Energy Metabolism
Humans
Neoplasms* / pathology
Neoplasms* / therapy
Precision Medicine