Circular RNAs (circRNAs) are a type of covalently closed RNA molecules, which are mainly formed by back splicing of a precursor mRNA upstream exon into a downstream exon. Abnormally expressed circRNAs can modulate gene transcription by indirectly interacting with microRNAs (miRNAs). According to the current studies, circGFRA1 has been suggested to be upregulated in various cancers. circGFRA1 (hsa_circ_005239) is a type of cancer-related circRNA, which is predicted to be originated from the GFRA1 on chromosome 10. circGFRA1 can act as a sponge for several miRNAs, including miR-34a, miR-1228, miR-361-5p, miR-149, miR-498, miR-188-3p, miR-3064-5p, miR-449a. Additionally, it can regulate signaling pathways such as TGF-β and PI3K/ AKT. circGFRA1 upregulation has been correlated with patients' poor overall survival in diverse cancers. In the present review, we have summarized the oncogenic effect of circGFRA1 in various cancers according to the adopted criteria from in vitro, in vivo, and clinical research. Moreover, functional enrichment analysis was performed on the circGFRA1 host gene and its protein interaction network to detect gene ontology and related pathways.
Keywords: Biomarkers; CircGFRA1; Circular RNA; Gene expression; Neoplasms.
Copyright © 2023 Elsevier GmbH. All rights reserved.