Some flies do not play ping-pong

PLoS Biol. 2023 Jun 7;21(6):e3002152. doi: 10.1371/journal.pbio.3002152. eCollection 2023 Jun.

Abstract

Genome integrity in animals depends on silencing of mobile elements by Piwi-interacting RNAs (piRNAs). A new study in this issue of PLOS Biology reveals recent evolutionary losses of key piRNA biogenesis factors in flies, highlighting adaptability by rapid shift to alternative piRNA biogenesis strategies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Biological Evolution
  • Drosophila Proteins* / genetics
  • Drosophila* / genetics
  • Piwi-Interacting RNA
  • RNA, Small Interfering / genetics

Substances

  • Piwi-Interacting RNA
  • RNA, Small Interfering
  • Drosophila Proteins

Grants and funding

This work was supported by a European Research Council consolidator grant under the Horizon 2020 program (863809 to YM). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.