Sampling volume assessment for wearable multimodal optical diagnostic device

Abstract

The process and results of numerical Monte Carlo simulation of optical radiation propagation in laser Doppler flowmetry (LDF) and fluorescence spectroscopy (FS) channels of a wearable diagnostic multimodal device are described in this paper. To achieve the goal, a multilayer skin model with different parameters of blood and melanin content and different distances between sources and radiation receivers was designed. The changes in the sampling (diagnostic) volume depending on the anatomical features of the biological tissues, as well as on the technical parameters of the device were shown. Depending on the scattering media optical properties and the source-detector configuration of the device, the diagnostic volume can range from 2 to 7 mm³ . The obtained results allow the formation of specialized medical and technical requirements for wearable multimodal devices implementing LDF and FS channels.

Keywords: Monte Carlo simulations; fluorescence spectroscopy; laser doppler flowmetry; optical noninvasive diagnostics; optical properties; wearable device.