Distinct profiles of host responses between plasma and lower respiratory tract during acute respiratory failure

Georgios D Kitsios; Seyed Mehdi Nouraie; Shulin Qin; Yingze Zhang; Prabir Ray; Anuradha Ray; Janet S Lee; Alison Morris; Bryan J McVerry; William Bain

doi:10.1183/23120541.00743-2022

Distinct profiles of host responses between plasma and lower respiratory tract during acute respiratory failure

ERJ Open Res. 2023 Jun 5;9(3):00743-2022. doi: 10.1183/23120541.00743-2022. eCollection 2023 May.

Authors

Georgios D Kitsios^{1

2

3}, Seyed Mehdi Nouraie^{1

2}, Shulin Qin^{1

3}, Yingze Zhang^{1

2}, Prabir Ray^{1

2}, Anuradha Ray^{1

2}, Janet S Lee^{1

2}, Alison Morris^{1

2

3}, Bryan J McVerry^{1

2

3}, William Bain^{1

2

4}

Affiliations

¹ Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
² Acute Lung Injury Center of Excellence, University of Pittsburgh, Pittsburgh, PA, USA.
³ Center for Medicine and the Microbiome, University of Pittsburgh, Pittsburgh, PA, USA.
⁴ Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA.

Abstract

Current plasma-based subphenotyping approaches in acute respiratory failure represent host responses at a systemic level but do not capture important differences in lower respiratory tract biology https://bit.ly/40kTdDG.

Grants and funding

IK2 BX004886/BX/BLRD VA/United States