Interleukin (IL)-36 is a family of cytokines that belongs to the larger IL-1 superfamily. IL-36 agonist/antagonist binds to the interleukin-36 receptor involving in physiological inflammation regulation and pathogenesis of many inflammatory diseases. In inflammatory joint diseases, the expression of IL-36 changes, and some studies have initially explored the role of IL-36 in these diseases. In psoriatic arthritis, IL-36 signal mediates plasma cell and fibroblast-like synoviocyte crosstalk presenting IL-36 agonist/antagonist imbalance. In rheumatoid arthritis, IL-36 agonists induce fibroblast-like synoviocyte to produce pro-inflammatory factors, while IL-36 antagonist deficiency leads to lesion progression. In osteoarthritis, IL-36 agonists induce chondrocytes to produce catabolic enzymes and pro-inflammatory factors. This article reviews the expression and function of IL-36 in different inflammatory joint diseases to provide a reference for revealing their pathogenic mechanisms and discovering therapeutic targets.
白介素（IL）-36是属于IL-1超家族的一组细胞因子，IL-36激动剂/拮抗剂与IL-36受体结合，在生理性炎症调控以及多种炎症性疾病的发病过程中发挥作用。在关节炎性疾病中，IL-36相关因子的表达水平发生一系列改变：银屑病关节炎中，IL-36信号介导浆细胞-成纤维细胞样滑膜细胞串扰并表现出IL-36激动剂/拮抗剂失衡；类风湿关节炎中，IL-36激动剂诱导成纤维细胞样滑膜细胞产生促炎性细胞因子，IL-36拮抗剂缺失引起病变进展；骨关节炎中，IL-36激动剂诱导软骨细胞产生分解代谢酶和促炎因子。本文综述了IL-36在不同关节炎性疾病中的表达和功能，以期为进一步研究提供参考。.
Keywords: Interleukin-36; Osteoarthritis; Psoriatic arthritis; Review; Rheumatoid arthritis.