A novel tunable metal-clad planar waveguide with 0.62PMN-0.38PT material for detection of cancer cells

J Biophotonics. 2023 Sep;16(9):e202300148. doi: 10.1002/jbio.202300148. Epub 2023 Jun 14.

Abstract

A dynamically tunable metal clad planar waveguide having 0.62PMN-0.38PT material is simulated and optimized for detection of cancer cells. Angular interrogation of the TE0 mode of waveguide shows that critical angle increases greater than the resonance angle with increasing of cover refractive index, which limits the detection range of waveguide. To overcome this limitation, proposed waveguide applies a potential on the PMN-PT adlayer. Although a sensitivity of 105.42 degree/RIU was achieved at 70 Volts in testing the proposed waveguide, it was found that the optimal performance parameters were obtained at 60 Volts. At this voltage, the waveguide demonstrated detection range 1.3330-1.5030, a detection accuracy 2393.33, and a figure of merit 2243.59 RIU-1 , which enabled the detection of the entire range of the targeted cancer cells. Therefore, it is recommended to apply a potential of 60 Volts to achieve the best performance from the proposed waveguide.

Keywords: PMN-PT material; cancer cells; detection accuracy; figure of merit; metal clad planar waveguide; sensitivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Metals*
  • Neoplasms* / diagnostic imaging
  • Vibration

Substances

  • Metals