Prenylated-coumarins from Gmelina arborea and evaluation for neurotrophic activity

Miwa Kubo; Ryo Irimajiri; Mitsuki Kawata; Yuta Takahashi; Kana Hayashi; Michiyo Matsuno; Kenichi Harada; Norihito Ikui; Hajime Mizukami; Nobuo Kawahara; Yoshiyasu Fukuyama

doi:10.1016/j.phytochem.2023.113721

Prenylated-coumarins from Gmelina arborea and evaluation for neurotrophic activity

Phytochemistry. 2023 Sep:213:113721. doi: 10.1016/j.phytochem.2023.113721. Epub 2023 Jun 4.

Affiliations

¹ Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180, Yamashiro-cho, Tokushima, 770-8514, Japan. Electronic address: miwa-k@ph.bunri-u.ac.jp.
² Faculty of Pharmaceutical Sciences, Tokushima Bunri University, 180, Yamashiro-cho, Tokushima, 770-8514, Japan.
³ The Kochi Prefectural Makino Botanical Garden, 4200-6, Godaisan, Kochi, 781-8125, Japan.

PMID: 37279871
DOI: 10.1016/j.phytochem.2023.113721

Abstract

A MeOH extract of the stem of Gmelina arborea Roxb. ex Sm. (Lamiaceae) exhibited neurite outgrowth-promoting activity in NGF-mediated PC12 cells. Bioassay-guided fractionation resulted in the isolation of eight previously undescribed prenylated coumarin compounds along with nine known compounds. Structural elucidation of these compounds was accomplished by analysis of extensive spectroscopic data, comparison with the literature, and chemical reactions. It was the first time to find prenylated coumarin compounds from G. arborea. Among the isolated compounds, N-methylflindersine and artanin showed neurite outgrowth-promoting activity in NGF-mediated PC12 cells.

Keywords: Coumarin; Gmelina arborea Roxb. ex Sm.; Lamiaceae; Neurotrophic activity; PC12 cells.

MeSH terms

Animals
Coumarins* / pharmacology
Neurites
PC12 Cells
Rats
Verbenaceae* / chemistry

Substances

Coumarins