Application of polyvinyl alcohol/chitosan copolymer hydrogels in biomedicine: A review

Int J Biol Macromol. 2023 Jul 1;242(Pt 4):125192. doi: 10.1016/j.ijbiomac.2023.125192. Epub 2023 Jun 3.

Abstract

Hydrogels is a hydrophilic, cross-linked polymer of three-dimensional network structures. The application of hydrogels prepared from a single polymer in the biomedical field has many drawbacks. The functional blend of polyvinyl alcohol and chitosan allows hydrogels to have better and more desirable properties than those produced from a single polymer, which is a good biomaterial for development and design. In this paper, we have reviewed the progress in the application of polyvinyl alcohol/chitosan composite hydrogels in various medical fields, the different cross-linking agents and cross-linking methods, and the research progress in the optimization of composite hydrogels for their subsequent wide range of biomedical applications.

Keywords: Biomedical engineering; Chitosan; Composite hydrogel; Polyvinyl alcohol; Review.

Publication types

  • Review

MeSH terms

  • Biocompatible Materials / chemistry
  • Chitosan* / chemistry
  • Hydrogels / chemistry
  • Polyvinyl Alcohol / chemistry

Substances

  • Chitosan
  • polyvinyl alcohol hydrogel
  • Polyvinyl Alcohol
  • Biocompatible Materials
  • Hydrogels