Mycobacterial type VII secretion systems

Nikolaos Famelis; Sebastian Geibel; Daan van Tol

doi:10.1515/hsz-2022-0350

Mycobacterial type VII secretion systems

Biol Chem. 2023 Jun 7;404(7):691-702. doi: 10.1515/hsz-2022-0350. Print 2023 Jun 27.

Authors

Nikolaos Famelis¹, Sebastian Geibel², Daan van Tol²

Affiliations

¹ Institute for Molecular Infection Biology, Julius Maximilian University of Würzburg, D-97080 Würzburg, Germany.
² Leiden Institute of Chemistry, Leiden University, NL-2333 CC Leiden, Netherlands.

PMID: 37276364
DOI: 10.1515/hsz-2022-0350

Abstract

Mycobacteria, such as the pathogen M. tuberculosis, utilize up to five paralogous type VII secretion systems to transport proteins across their cell envelope. Since these proteins associate in pairs that depend on each other for transport to a different extent, the secretion pathway to the bacterial surface remained challenging to address. Structural characterization of the inner-membrane embedded secretion machineries along with recent advances on the substrates' co-dependencies for transport allow for the first time more detailed and testable models for secretion.

Keywords: ESX; T7SS; pe-ppe; translocase; tuberculosis.

Publication types

Review

MeSH terms

Bacterial Proteins / metabolism
Bacterial Secretion Systems / metabolism
Cell Membrane / metabolism
Mycobacterium tuberculosis* / chemistry
Type VII Secretion Systems* / chemistry
Type VII Secretion Systems* / metabolism

Substances

Type VII Secretion Systems
Bacterial Proteins
Bacterial Secretion Systems