Therapeutic strategies to enhance immune response induced by multiple myeloma cells

Zhaoyun Liu; Chun Yang; Xiaohan Liu; Xintong Xu; Xianghong Zhao; Rong Fu

doi:10.3389/fimmu.2023.1169541

Therapeutic strategies to enhance immune response induced by multiple myeloma cells

Front Immunol. 2023 May 18:14:1169541. doi: 10.3389/fimmu.2023.1169541. eCollection 2023.

Authors

Zhaoyun Liu¹, Chun Yang¹, Xiaohan Liu¹, Xintong Xu¹, Xianghong Zhao¹, Rong Fu¹

Affiliation

¹ Department of Hematology, Tianjin Medical University General Hospital, Tianjin, China.

Abstract

Multiple myeloma (MM)as a haematological malignancy is still incurable. In addition to the presence of somatic genetic mutations in myeloma patients, the presence of immunosuppressive microenvironment greatly affects the outcome of treatment. Although the discovery of immunotherapy makes it possible to break the risk of high toxicity and side effects of traditional chemotherapeutic drugs, there are still obstacles of ineffective treatment or disease recurrence. In this review, we discuss therapeutic strategies to further enhance the specific anti-tumor immune response by activating the immunogenicity of MM cells themselves. New ideas for future myeloma therapeutic approaches are provided.

Keywords: immunogenic cell death; immunotherapy; multiple myeloma; neoantigen; vaccine.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Hematologic Neoplasms*
Humans
Immunity
Immunotherapy
Multiple Myeloma* / drug therapy
Neoplasm Recurrence, Local
Tumor Microenvironment

Grants and funding

This work was supported by the National Natural Science Foundation of China Youth Project (grant no.81900131,82000219), the National Natural Science Foundation of China Youth Project (grant no. 8210010129), the Tianjin Municipal Natural Science Foundation (grant no.18JCQNJC80400, 19JCZDJC32900), the Tianjin EducationCommission Research Project (grant no.2018KJ043,20140118),the Tianjin Education Commission Research Project (grant no. 2018KJ045), and the Tianjin Science and Technology Planning Project (no. 20YFZCSY00060).Tianjin Municipal Health Commission Youth Project (grant no. TJWJ2021QN001); Medjaden Academy & Research Foundation for Young Scientists (Grant No. MJR20221011);Tianjin Key Medical Discipline(Specialty) Construction project(GrantTJYXZDXK-028A).