Metastasis in neuroblastoma: the MYCN question

Swapnil Parashram Bhavsar

doi:10.3389/fonc.2023.1196861

Metastasis in neuroblastoma: the MYCN question

Front Oncol. 2023 May 18:13:1196861. doi: 10.3389/fonc.2023.1196861. eCollection 2023.

Author

Swapnil Parashram Bhavsar¹

Affiliation

¹ Pediatric Research Group, Department of Clinical Medicine, Faculty of Health Sciences, UiT - The Arctic University of Norway, Tromsø, Norway.

Abstract

Oncogenic drivers like MYCN in neuroblastoma subsets continues to present a significant challenge owing to its strong correlation with high-risk metastatic disease and poor prognosis. However, only a limited number of MYCN-regulatory proteins associated with tumor initiation and progression have been elucidated. In this minireview, I summarize the recent progress in understanding the functional role of MYCN and its regulatory partners in neuroblastoma metastasis.

Keywords: MYCN; metastasis; neuroblastoma; oncogene; poor prognosis.

Publication types

Review

Grants and funding

This study was supported by research grant from the Barnekreftforeningen (Project number: 210009). The publication charges for this article have been funded by a grant from the publication fund of UiT - The Arctic University of Norway. The funding organizations have no role in the design of the study, analysis, and interpretation of the data and in writing the manuscript.