Association between DRD2/ANKK1 rs1800497 C > T polymorphism and post-traumatic stress disorder susceptibility: a multivariate meta-analysis

Yu-Ming Niu; Jie Zhang; Hong Tang; Lu-Hua Cao; Ting-Yun Jiang; Yuan-Yuan Hu

doi:10.3389/fnins.2023.1102573

Association between DRD2/ANKK1 rs1800497 C > T polymorphism and post-traumatic stress disorder susceptibility: a multivariate meta-analysis

Front Neurosci. 2023 May 18:17:1102573. doi: 10.3389/fnins.2023.1102573. eCollection 2023.

Authors

Yu-Ming Niu^#^{1

2

3}, Jie Zhang^#^{2

3}, Hong Tang³, Lu-Hua Cao⁴, Ting-Yun Jiang², Yuan-Yuan Hu¹

Affiliations

¹ Department of Stomatology and Center for Evidence-Based Medicine and Clinical Research, Gongli Hospital of Shanghai Pudong New Area, Shanghai, China.
² Department of Psychiatry and Joint Laboratory of Psychiatric Genetic Research, The Third People's Hospital of Zhongshan, Zhongshan, Guangdong Province, China.
³ Department of Psychiatry, Gannan Medical University, Ganzhou, Jiangxi Province, China.
⁴ Information Department, Gongli Hospital of Shanghai Pudong New Area, Shanghai, China.

^# Contributed equally.

Abstract

Background: Previous studies have suggested that the DRD2/ANKK1 rs1800497 C > T polymorphism plays a critical role in the risk of post-traumatic stress disorder (PTSD). However, published data are inconsistent or even contradictory. Therefore, we conducted a meta-analysis to explore the underlying correlation between the rs1800497 C > T polymorphism and PTSD risk.

Materials and methods: A total of five online databases were searched, and all related studies were reviewed up to 1 October 2022. Critical information was extracted, and quality assessment was conducted for all included studies. Multivariate meta-analyses were performed for the genetic model choice, and the odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated to examine the statistical power of the genetic models. In addition, heterogeneity, sensitivity, cumulative analysis, and publication bias were analyzed to guarantee statistical power.

Result: Overall, 12 observational studies involving 5,515 subjects were included and analyzed in this meta-analysis. Multivariate analysis indicated that a co-dominant genetic model was most likely the best choice. Pooled results revealed an elevated PTSD risk in mutated homozygote TT carriers in the general population (TT vs. CC: OR = 1.73, 95% CI = 1.14-2.62, P = 0.01, I² = 58.9%) and other specific subgroups. Moreover, similar results were observed in other genetic models using univariate analysis.

Conclusion: Current evidence suggests that the DRD2/ANKK1 rs1800497 C > T polymorphism may contribute to PTSD susceptibility.

Keywords: dopamine receptor D2; multivariate analysis; polymorphism; post-traumatic stress disorder; susceptibility.

Grants and funding

This study was supported by the Project of the Pudong Health Committee (Grant No. PW2022A-63), the Health Commission of Hubei Province Scientific Research Project (Grant No. WJ2021M049), the Social Welfare Science and Technology Research Major Project in Zhongshan (Grant Nos. 2021B3019 and 2021B1113), and the Medical Science and Technology Research Funding Project of Guangdong (No. A2023194). The funders had no roles in study design, data collection and analysis, the decision to publish, or the preparation of the manuscript.