Stem cell sources from human biological waste material: a role for the umbilical cord and dental pulp stem cells for regenerative medicine

Hum Cell. 2023 Jul;36(4):1312-1325. doi: 10.1007/s13577-023-00922-6. Epub 2023 Jun 5.

Abstract

Stem cell research with biological waste material is an area that holds promise to revolutionize treatment modalities and clinical practice. The interest in surgical remnants is increasing with time as research on human embryonic stem cells remains controversial due to legal and ethical issues. Perhaps, these restrictions are the motivation for the use of alternative mesenchymal stem cell (MSC) sources in the regenerative field. Stem cells (SCs) of Umbilical Cord (UC) and Dental Pulp (DP) have almost similar biological characteristics to other MSCs and can differentiate into a number of cell lineages with enormous potential future prospects. A concise critical observation of UC-MSCs and DP-MSCs is presented here reviewing articles from the last two decades along with other stem cell sources from different biological waste materials.

Keywords: Biological waste; Dental pulp; Stem cells; Surgical remnant; Umbilical cord.

Publication types

  • Review

MeSH terms

  • Cell Differentiation
  • Cell Proliferation
  • Dental Pulp
  • Humans
  • Mesenchymal Stem Cells*
  • Regenerative Medicine*
  • Umbilical Cord