Construction of "peptide-hemin/DNA" hybrid-complexes and their peroxidase activities

Jing Liu; Taozhe Zhang; Jinyang Feng; Yue Cui; Li Zhang; Yunong Wang; Meiyu Cui; Donghao Li; Hulin Tai

doi:10.1039/d3cc00752a

Construction of "peptide-hemin/DNA" hybrid-complexes and their peroxidase activities

Chem Commun (Camb). 2023 Jun 20;59(50):7811-7814. doi: 10.1039/d3cc00752a.

Authors

Jing Liu¹, Taozhe Zhang¹, Jinyang Feng¹, Yue Cui¹, Li Zhang¹, Yunong Wang¹, Meiyu Cui¹, Donghao Li¹, Hulin Tai^{1

2

3}

Affiliations

¹ Interdisciplinary Program of Biological Functional Molecules (College of Integration Science), Department of Chemistry (College of Science), Yanbian University, Yanji 133002, China. taihulin@ybu.edu.cn.
² National Demonstration Centre for Experimental Chemistry Education, Yanbian University, Yanji 133002, Jilin, China.
³ Jilin Key Laboratory for Immune and Targeting Research on Common Allergic Diseases, Yanbian University, Yanji 133002, Jilin, China.

PMID: 37272293
DOI: 10.1039/d3cc00752a

Abstract

N-Acetylated microperoxidase-11 and G-quadruplex DNA are shown to form a stable "peptide-hemin/DNA" hybrid-complex, in which the peroxidase activity at the interface between hemin and the G-quartet planes exponentially increases with increasing K_a value.

MeSH terms

Biosensing Techniques*
DNA
DNA, Catalytic* / metabolism
G-Quadruplexes*
Hemin
Peroxidase / metabolism
Peroxidases

Substances

Hemin
DNA
Peroxidases
DNA, Catalytic
Peroxidase