Discovering effector domains in human transcription factors

Sarah E Gilbertson; Amy S Weinmann

doi:10.1016/j.it.2023.05.006

Discovering effector domains in human transcription factors

Trends Immunol. 2023 Jul;44(7):493-495. doi: 10.1016/j.it.2023.05.006. Epub 2023 Jun 1.

Authors

Sarah E Gilbertson¹, Amy S Weinmann²

Affiliations

¹ Department of Microbiology, University of Alabama at Birmingham, AL 35294, USA.
² Department of Microbiology, University of Alabama at Birmingham, AL 35294, USA. Electronic address: weinmann@uab.edu.

PMID: 37270301
DOI: 10.1016/j.it.2023.05.006

Abstract

Genomic studies are transforming knowledge about the epigenetic, transcription factor, and 3D landscapes of the genome. However, comprehensive information is lacking about the effector domains used by transcription factors to influence gene expression. Addressing this gap, DelRosso et al. developed a high-throughput screen to discover effector domains in human regulatory factors.

MeSH terms

Gene Expression Regulation*
Genome
Genomics
Humans
Transcription Factors* / genetics
Transcription Factors* / metabolism

Substances

Transcription Factors