Alterations in pulmonary vasomotor modulators post aerobic exercise training in non-alcoholic fatty liver disease

Respir Physiol Neurobiol. 2023 Aug:314:104089. doi: 10.1016/j.resp.2023.104089. Epub 2023 Jun 1.

Abstract

This study investigated the impact of exercise training on major pulmonary vasomotor mediators and receptors including endothelial nitric oxide synthase (eNOS) inducible NOS (iNOS), endothelin-1 (ET-1), ET-1 receptors A (ETA) and-B (ETB) in high-fat-high-carbohydrate (HFHC) induced non-alcoholic fatty liver disease (NAFLD). NAFLD increased iNOS, ET-1 and ETA (p < 0.05), but not ETB (p > 0.05). Exercise attenuated iNOS, ET-1 and ETA (p < 0.05)., but not ETB (p > 0.05) and eNOS (p > 0.05). Exercise training is beneficial for pulmonary vasculature in NAFLD.

Keywords: ENOS; ET-1; Exercise; INOS; NAFLD; Pulmonary.

MeSH terms

  • Endothelin-1 / metabolism
  • Endothelin-1 / pharmacology
  • Exercise
  • Humans
  • Nitric Oxide Synthase Type II
  • Nitric Oxide Synthase Type III
  • Nitric Oxide Synthase* / metabolism
  • Non-alcoholic Fatty Liver Disease* / therapy
  • RNA, Messenger
  • Receptor, Endothelin A

Substances

  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type II
  • RNA, Messenger
  • Nitric Oxide Synthase Type III
  • Endothelin-1
  • Receptor, Endothelin A