Despite the largely tranquil environment in which humans live, a chemical terrorism attack is still a public safety problem, for which the capacity to quickly and accurately detect chemical warfare agents (CWAs) constitute a significant barrier. In this study, a straightforward fluorescent probe based on dinitrophenylhydrazine has been synthesised. It exhibits great selectivity and sensitivity for the nerve agent mimicking dimethyl chlorophosphate (DMCP) in the MeOH solution. Dinitrophenylhydrazine-oxacalix[4]arene (DPHOC), a 2,4-dinitrophenylhydrazine (2,4-DNPH) derivative, was synthesised and characterized with NMR and ESI-MS. Photophysical behavior, specially spectrofluorometric analysis was introduced to investigate the sensing phenomena of DPHOC toward dimethyl chlorophosphate (DMCP). The LOD of DPHOC toward DMCP was determined to be 2.1 µM, with a linear range from 5 to 50 µM (R2 = 0.99933). Moreover, DPHOC has been proven to be a promising probe toward the real time detection of DMCP.
Keywords: Nerve agent mimics; Organophosphorous compounds; Oxacalix[4]arene.
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