Synthesis of 3-Azabicyclo[3.1.0]hexane Derivates

Abstract

3-Azabicyclo[3.1.0]hexanes are an important class of nitrogen-containing heterocycles that have been found to be key structural features in a wide range of biologically active natural products, drugs, and agrochemicals. As a cutting-edge area, the synthesis of these derivatives has made spectacular progress in recent decades, with various transition-metal-catalyzed and transition-metal-free catalytic systems being developed. In this review, we provide an overview of recent advances in the efficient methods for the synthesis of 3-azabicyclo[3.1.0]hexane derivatives since 2010, emphasizing the scope of substrates and synthesis' applications, as well as the mechanisms of these reactions.

Keywords: 3-azabicyclo[3.1.0]hexane derivates; cyclopropanes; nitrogen-containing heterocycles; transition-metal-catalyzed; transition-metal-free-catalyzed.