In vitro and in vivo efficacy of Molnupiravir against Zika virus infections

Virol Sin. 2023 Aug;38(4):639-642. doi: 10.1016/j.virs.2023.05.011. Epub 2023 Jun 1.

Abstract

  1. Molnupiravir exhibits effective antiviral activity against ZIKV in vitro.

  2. Intraperitoneal administration of Molnupiravir protects mice from lethal ZIKV challenge.

  3. Molnupiravir might act on the replication phase of the ZIKV life cycle.

Publication types

  • Letter

MeSH terms

  • Antiviral Agents / therapeutic use
  • Cytidine
  • Humans
  • Hydroxylamines / therapeutic use
  • Zika Virus Infection* / drug therapy
  • Zika Virus*

Substances

  • molnupiravir
  • Hydroxylamines
  • Cytidine
  • Antiviral Agents