Senescent macrophages: A new "old" player in lung cancer development

Lin Zhou; Marcus Ruscetti

doi:10.1016/j.ccell.2023.05.008

Senescent macrophages: A new "old" player in lung cancer development

Cancer Cell. 2023 Jul 10;41(7):1201-1203. doi: 10.1016/j.ccell.2023.05.008. Epub 2023 Jun 1.

Authors

Lin Zhou¹, Marcus Ruscetti²

Affiliations

¹ Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
² Department of Molecular, Cell, and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA; Immunology and Microbiology Program, University of Massachusetts Chan Medical School, Worcester, MA, USA; Cancer Center, University of Massachusetts Chan Medical School, Worcester, MA, USA. Electronic address: marcus.ruscetti@umassmed.edu.

Abstract

Senescent cells accumulate following oncogene induction, but their role in transformation remains unclear. Prieto et al. and Haston et al. found that senescent cells in premalignant lung lesions are mainly macrophages that promote lung tumorigenesis, and removing them through senolytic approaches can prevent malignant progression.

Publication types

Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Comment

MeSH terms

Cellular Senescence
Humans
Lung
Lung Neoplasms*
Macrophages
Precancerous Conditions*

Abstract

Publication types

MeSH terms

Grants and funding