LncRNA SOCS2-AS1 promotes the progression of papillary thyroid cancer by destabilizing p53 protein

Biochem Biophys Res Commun. 2023 Aug 20:669:95-102. doi: 10.1016/j.bbrc.2023.05.080. Epub 2023 May 22.

Abstract

Long noncoding RNAs (lncRNAs) have been shown to contribute to tumorigenesis and cancer progression. However, neither the dysregulation nor the functions of anti-sense lncRNAs in papillary thyroid carcinoma (PTC) have been exhaustively studied. In this study, we accessed The Cancer Genome Atlas (TCGA) database and discovered that the natural antisense lncRNA SOCS2-AS1 is highly expressed in PTC and that patients with a higher level of SOCS2-AS1 had a poor prognosis. Furthermore, loss- and gain-function assays demonstrated that SOCS2-AS1 promotes PTC cell proliferation and growth both in vitro and in vivo. In addition, we demonstrated that SOCS2-AS1 regulates the rate of fatty acid oxidation (FAO) in PTC cells. Analysis of the mechanism revealed that SOCS2-AS1 binds to p53 and controls its stability in PTC cell lines. Overall, our findings showed that the natural antisense lncRNA SOCS2-AS1 stimulates the degradation of p53 and enhances PTC cell proliferation and the FAO rate.

Keywords: Cell proliferation; Fatty acid oxidation; LncRNA; SOCS2-AS1; p53 signaling.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Cell Movement / genetics
  • Cell Proliferation / genetics
  • Gene Expression Regulation, Neoplastic
  • Humans
  • MicroRNAs* / genetics
  • RNA, Antisense / genetics
  • RNA, Long Noncoding* / genetics
  • Suppressor of Cytokine Signaling Proteins / genetics
  • Thyroid Cancer, Papillary / genetics
  • Thyroid Cancer, Papillary / pathology
  • Thyroid Neoplasms* / pathology
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism

Substances

  • RNA, Long Noncoding
  • Tumor Suppressor Protein p53
  • RNA, Antisense
  • MicroRNAs
  • SOCS2 protein, human
  • Suppressor of Cytokine Signaling Proteins