Exosome and exosomal contents in schizophrenia

Tingkai Zhang; Yehong Fang; Liangliang Wang; Lin Gu; Jinsong Tang

doi:10.1016/j.jpsychires.2023.05.072

Exosome and exosomal contents in schizophrenia

J Psychiatr Res. 2023 Jul:163:365-371. doi: 10.1016/j.jpsychires.2023.05.072. Epub 2023 May 25.

Authors

Tingkai Zhang¹, Yehong Fang¹, Liangliang Wang¹, Lin Gu², Jinsong Tang³

Affiliations

¹ Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
² RIKEN AIP, Tokyo, Japan; Research Center for Advanced Science and Technology (RCAST), The University of Tokyo, Tokyo, Japan.
³ Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China. Electronic address: tangjinsong@zju.edu.cn.

PMID: 37267733
DOI: 10.1016/j.jpsychires.2023.05.072

Abstract

Schizophrenia (SCZ) is a severe mental disorder that affects approximately 1% general population worldwide and poses a considerable burden to society. Despite decades of research, its etiology remains unclear, and diagnosis remains challenging due to its heterogeneous symptoms. Exosomes play a crucial role in intercellular communication, and their contents, including nucleotides, proteins and metabolites, have been linked to various diseases. Recent studies have implicated exosome abnormalities in the pathogenesis of schizophrenia. In this review, we discuss the current understanding of the relationship between exosomes and schizophrenia, focusing on the role of exosomal contents in this disease. We summarize recent findings and provide insights into the potential use of exosomes as biomarkers for the diagnosis and treatment of schizophrenia.

Keywords: Biomarker; Exosome; Omics; Schizophrenia; miRNA.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers / metabolism
Exosomes* / metabolism
Humans
MicroRNAs* / metabolism
Schizophrenia* / metabolism

Substances

Biomarkers
MicroRNAs