Small but mighty: How microRNAs drive the deadly progression of cholangiocarcinoma

Abduladheem Turki Jalil; Mohanad Ali Abdulhadi; Lubna R Al-Ameer; Luay Ali Khaleel; Sada Jasim Abdulameer; Ameer Mezher Hadi; Muna S Merza; Rahman S Zabibah; Ahmed Ali

doi:10.1016/j.prp.2023.154565

Small but mighty: How microRNAs drive the deadly progression of cholangiocarcinoma

Pathol Res Pract. 2023 Jul:247:154565. doi: 10.1016/j.prp.2023.154565. Epub 2023 May 21.

Authors

Abduladheem Turki Jalil¹, Mohanad Ali Abdulhadi², Lubna R Al-Ameer³, Luay Ali Khaleel⁴, Sada Jasim Abdulameer⁵, Ameer Mezher Hadi⁶, Muna S Merza⁷, Rahman S Zabibah⁸, Ahmed Ali⁹

Affiliations

¹ College of Medicine, University of Thi-Qar, Al-Nasiriya, Iraq.. Electronic address: abedalazeem799@gmail.com.
² Department of Medical Laboratory Techniques, Al-maarif University College, Al-Anbar, Iraq.
³ College of Pharmacy, Al-Zahraa University for Women, Iraq.
⁴ College of Dentistry, National University of Science and Technology, Dhi Qar, Iraq.
⁵ Biology Department, College of Education for Pure Science, Wasit University, Kut, Wasit, Iraq.
⁶ DNA Research Center, University of Babylon, Babylon, Iraq.
⁷ Prosthetic dental Techniques Department, Al-Mustaqbal university College, Babylon, 51001, Iraq.
⁸ Medical Laboratory Technology Department, College of Medical Technology, The Islamic University, Najaf, Iraq.
⁹ Medical technical college, Al-Farahidi University, Baghdad, Iraq.

PMID: 37267725
DOI: 10.1016/j.prp.2023.154565

Abstract

Cholangiocarcinoma, also referred to as CCA, is a highly complex epithelial malignancy that can impact various organs and regions of the body, including the perihilar, intrahepatic, and distal organs. This cancer is characterized by the malignant growth of the epithelial lining in the bile ducts, which spans the entire biliary tree and is accountable for disease progression. The current state of affairs concerning CCA is concerning, with poor prognoses, high recurrence rates, and dismal long-term survival rates significantly burden healthcare facilities worldwide. Studies have identified numerous signaling pathways and molecules involved in the development and progression of CCA, including microRNAs, an important class of non-coding RNAs that have the ability to modulate these cellular signaling pathways significantly. In addition, microRNAs may serve as an innovative target for developing novel therapeutic approaches for CCA. In this review, we explore the underlying mechanisms and signaling pathways implicated in the initiation and progression of CCA, focusing on the future direction of utilizing microRNAs as a promising treatment option for this challenging malignancy.

Keywords: Biliary tract cancer; Cholangiocarcinoma; MicroRNAs; Progression.

Publication types

Review

MeSH terms

Bile Duct Neoplasms* / pathology
Bile Ducts
Bile Ducts, Intrahepatic / pathology
Cholangiocarcinoma* / pathology
Humans
MicroRNAs* / genetics

Substances

MicroRNAs