COVID-19 in Pregnant Patients at Term: Evolution of Coagulation Factors in Mild Forms throughout the Pandemic: Conventional Analysis and Logistic Regression

Catalina Filip; Roxana Covali; Demetra Socolov; Ioana Pavaleanu; Alexandru Carauleanu; Ioana Sadiye Scripcariu; Ingrid Andrada Vasilache; Mona Akad; Vasile Lucian Boiculese; Cristina Dimitriu; Tudor Butureanu; Alina Melinte; Cristiana Filip; Radu Florin Popa; Razvan Socolov

doi:10.26574/maedica.2023.18.1.67

COVID-19 in Pregnant Patients at Term: Evolution of Coagulation Factors in Mild Forms throughout the Pandemic: Conventional Analysis and Logistic Regression

Maedica (Bucur). 2023 Mar;18(1):67-73. doi: 10.26574/maedica.2023.18.1.67.

Authors

Affiliations

¹ Department of Vascular Surgery, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania.
² Department of Radiology, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, "Elena Doamna" Obstetrics and Gynecology University Hospital, 700115 Iasi, Romania.
³ Department of Obstetrics and Gynecology, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, "Cuza Voda" Obstetrics and Gynecology University Hospital, 700115 Iasi, Romania.
⁴ Department of Obstetrics and Gynecology, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, "Elena Doamna" Obstetrics and Gynecology University Hospital, 700115 Iasi, Romania.
⁵ Doctoral student, Department of Obstetrics and Gynecology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
⁶ Department of Statistics, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania.
⁷ Department of Biochemistry, "Grigore T. Popa" University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania.
⁸ Department of Obstetrics and Gynecology, Hereditas Hospital, 727325 Ipotesti, Romania.

Abstract

Aim: The evolution of coagulation factors in pregnant patients infected with SARS-CoV-2 during the pandemic is still debated. However, few studies have been carried out to evaluate the silent alterations of blood values in mild forms of the disease. Methods:A total of 153 pregnant patients with an asymptomatic form of COVID-19 and 306 healthy pregnant patients, who were admitted for delivery in our hospital between April 1, 2020 and March 1, 2022, were studied. The blood values harvested closest to the time of delivery were considered. Results:There was a significant variability in values of fibrinogen, prothrombin time, though these were still within normal limits. Conclusions:Pregnant patients with mild forms of COVID-19 displayed some blood alterations, even if they were asymptomatic for COVID-19.

Publication types

Editorial