Aniline-induced production of aniline-containing polyketides and related bicyclic polyketides by the Yellow River wetland-derived fungus Talaromyces funiculosus

Zhenhui Wang; Zhanlin Li; Chao Niu; Lanping Yang; Yangyang Zhai; Dehai Li; Guangwei Wu; Zhenzhen Zhang; Xueqian He

doi:10.3389/fmicb.2023.1200680

Aniline-induced production of aniline-containing polyketides and related bicyclic polyketides by the Yellow River wetland-derived fungus Talaromyces funiculosus

Front Microbiol. 2023 May 17:14:1200680. doi: 10.3389/fmicb.2023.1200680. eCollection 2023.

Authors

Zhenhui Wang¹, Zhanlin Li¹, Chao Niu¹, Lanping Yang¹, Yangyang Zhai¹, Dehai Li², Guangwei Wu³, Zhenzhen Zhang¹, Xueqian He¹

Affiliations

¹ School of Medicine, Henan Polytechnic University, Jiaozuo, China.
² Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
³ College of Chemical Engineering, Nanjing Forestry University, Nanjing, China.

Abstract

Introduction and methods: Silencing gene activation can effectively enrich the diversity of fungal secondary metabolites.

Results and discussion: Cultivation of the Yellow River wetland-derived fungus Talaromyces funiculosus HPU-Y01 with aniline led to the isolation of one new aniline-containing polyketide tanicutone A (1), two new bicyclic polyketides tanicutones B-C (2-3), a new related trienoic acid 8-methyldeca-2,4,6-trienoic acid (5), and a known compound 4. The planar structures and configurations of 1-5 were determined by NMR, MS, and ECD calculations. Compound 2 featured a key aldehyde group and showed promising inhibitory activity against Vibrio parahaemolyticus with a minimum inhibitory concentration (MIC) value of 0.17 μg/mL. This is a rare report of aniline-induced fungal production of tetrahydronaphthone polyketides.

Keywords: NMR; Talaromyces funiculosus; aniline; antimicrobial activity; tetrahydronaphthone polyketides.