Alveolar ridge preservation in post-extraction sockets using concentrated growth factors: a split-mouth, randomized, controlled clinical trial

Sadam Ahmed Elayah; Hamza Younis; Hao Cui; Xiang Liang; Karim Ahmed Sakran; Baleegh Alkadasi; Essam Ahmed Al-Moraissi; Mohammed Albadani; Wafa Al-Okad; Junbo Tu; Sijia Na

doi:10.3389/fendo.2023.1163696

Alveolar ridge preservation in post-extraction sockets using concentrated growth factors: a split-mouth, randomized, controlled clinical trial

Front Endocrinol (Lausanne). 2023 May 17:14:1163696. doi: 10.3389/fendo.2023.1163696. eCollection 2023.

Authors

Sadam Ahmed Elayah^{1

2

3

4}, Hamza Younis^{1

2}, Hao Cui^{1

2}, Xiang Liang^{1

2}, Karim Ahmed Sakran⁴, Baleegh Alkadasi⁴, Essam Ahmed Al-Moraissi⁵, Mohammed Albadani⁴, Wafa Al-Okad⁶, Junbo Tu^{1

2}, Sijia Na^{1

2}

Affiliations

¹ Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
² Department of Oral and Maxillofacial Surgery, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
³ State Key Laboratory of Oral Diseases and National Clinical Research Centre for Oral Diseases and Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
⁴ Department of Oral and Maxillofacial Surgery, College of Dentistry, Ibb University, Ibb, Yemen.
⁵ Department of Oral and Maxillofacial Surgery, College of Dentistry, Thamar University, Thamar, Yemen.
⁶ Department of Oral and Maxillofacial Surgery, College of Dentistry, Sana'a University, Sana'a, Yemen.

Abstract

Aim: The aim of this clinical trial was to assess the impact of autologous concentrated growth factor (CGF) as a socket-filling material and its ridge preservation properties following the lower third molar extraction.

Materials and methods: A total of 60 sides of 30 participants who had completely symmetrical bilateral impacted lower third molars were enrolled. The primary outcome variables of the study were bone height and width, bone density, and socket surface area in the coronal section. Cone beam computed tomography images were obtained immediately after surgery and three months after surgery as a temporal measure. Follow-up data were compared to the baseline using paired and unpaired t-tests.

Results: CGF sites had higher values in height and width when compared to control sites (Buccal wall 32.9 ± 3.5 vs 29.4 ± 4.3 mm, Lingual wall 25.4 ± 3.5 vs 23.1 ± 4 mm, and Alveolar bone width 21.07 ± 1.55vs19.53 ± 1.90 mm, respectively). Bone density showed significantly higher values in CGF sites than in control sites (Coronal half 200 ± 127.3 vs -84.1 ± 121.3 and Apical half 406.5 ± 103 vs 64.2 ± 158.6, respectively). There was a significant difference between both sites in the reduction of the periodontal pockets.

Conclusion: CGF application following surgical extraction provides an easy, low-cost, and efficient option for alveolar ridge preservation. Thus, the use of CGF by dentists during dental extractions may be encouraged, particularly when alveolar ridge preservation is required.

Clinical trial registration: TCTR identification, TCTR20221028003.

Keywords: CGF; alveolar ridge; extraction; impacted teeth; platelet; regeneration.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

Cone-Beam Computed Tomography
Humans
Tooth Extraction* / adverse effects
Tooth Socket* / diagnostic imaging
Tooth Socket* / surgery

Grants and funding

National Natural Science Foundation of China (Grant No. 81960194); Natural Science Foundation of Shaanxi Province, China (Grant No. 2020JQ563); Basic Scientific Research Business Expenses Project of Xi’an Jiaotong University, China (Grant No. xzy012020048).