Aqueous mediated iodine catalyzed C-N coupling followed by C-C coupling towards 5 H-pyrazino[2,3- b]indoles

Debasish Bera; Rajib Sarkar; Pinaki Saha; Prasanta Ghosh; Chhanda Mukhopadhyay

doi:10.1039/d3cc01631e

Aqueous mediated iodine catalyzed C-N coupling followed by C-C coupling towards 5 H-pyrazino[2,3- b]indoles

Chem Commun (Camb). 2023 Jun 20;59(50):7771-7774. doi: 10.1039/d3cc01631e.

Authors

Debasish Bera¹, Rajib Sarkar¹, Pinaki Saha², Prasanta Ghosh², Chhanda Mukhopadhyay¹

Affiliations

¹ Department of Chemistry, University of Calcutta, 92 APC Road, Kolkata-700009, India. cmukhop@yahoo.co.in.
² Department of Chemistry, Ramakrishna Mission Residential College (Autonomous), Narendrapur, Kolkata-700103, India.

PMID: 37264649
DOI: 10.1039/d3cc01631e

Abstract

Our study describes a new development featuring iodine-catalyzed two consecutive oxidative cross-coupling reactions involving C_α(sp³)-H of benzyl amines followed by intramolecular cyclization in water under air. Here, C-N coupling followed by C-C coupling occurs in a green environment to provide a variety of 5H-pyrazino[2,3-b]indoles within a short time period.